Staphylococcus aureus - aspects of pathogenesis and molecular epidemiology
نویسنده
چکیده
............................................................................................................. 1 SAMMANFATTNING PÅ SVENSKA............................................................... 3 LIST OF PAPERS................................................................................................... 5 ABBREVIATIONS................................................................................................. 7 INTRODUCTION................................................................................................... 9 Staphylococcus aureus...................................................................................... 9 Background...................................................................................................... 9 Epidemiology................................................................................................... 10 Antibiotic resistance....................................................................................... 11 Methicillin-resistant Staphylococcus aureus.............................................. 12 Virulence factors and strategies................................................................... 14 Adhesion to host............................................................................................. 20 The host.................................................................................................................. 25 Innate immunity............................................................................................. 25 Endothelial cells.............................................................................................. 28 Typing methods................................................................................................... 30 Conventional typing................................................................................ 31 Phage typing................................................................................................. 31 Molecular typing methods............................................................................ 32 Pulsed field gel electrophoresis.................................................................. 32 Multilocus sequence typing......................................................................... 33 spa typing...................................................................................................... 35
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